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ALX-5407 hydrochloride

CAS No. 200006-08-2

ALX-5407 hydrochloride( ALX5407 )

Catalog No. M13122 CAS No. 200006-08-2

ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    ALX-5407 hydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM.
  • Description
    ALX-5407 is a potent, selective, orally active inhibitor of GlyT1 glycine transporter with IC50 of 3 nM; has little or no activity at the GlyT2 transporter, at other binding sites for glycine, or at other neurotransmitter transporters; increases free glycine levels in rat prefrontal cortex (10 mg/kg, p.o.).Schizophrenia Discontinued.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    ALX5407
  • Pathway
    Membrane Transporter/Ion Channel
  • Target
    GlyT
  • Recptor
    GlyT
  • Research Area
    Neurological Disease
  • Indication
    Schizophrenia

Chemical Information

  • CAS Number
    200006-08-2
  • Formula Weight
    429.916
  • Molecular Formula
    C24H25ClFNO3
  • Purity
    >98% (HPLC)
  • Solubility
    In Vitro:?DMSO : 100 mg/mL (232.61 mM)
  • SMILES
    CN(CCC(C1=CC=C(C=C1)F)OC2=CC=C(C=C2)C3=CC=CC=C3)CC(=O)O.Cl
  • Chemical Name
    N-[(3R)-3-([1,1'-Biphenyl]-4-yloxy)-3-(4-fluorophenyl)propyl]-N-methylglycine hydrochloride

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Atkinson BN, et al. Mol Pharmacol. 2001 Dec;60(6):1414-20. 2. Perry KW, et al. Neuropharmacology. 2008 Oct;55(5):743-54.
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